RT Book, Section A1 Ciccone, Charles D. SR Print(0) ID 1135036592 T1 Treatment of Coagulation Disorders and Hyperlipidemia T2 Pharmacology in Rehabilitation YR 2016 FD 2016 PB F. A. Davis Company PP New York, NY SN 9780803640290 LK fadavisat.mhmedical.com/content.aspx?aid=1135036592 RD 2024/03/29 AB Blood coagulation, or hemostasis, is necessary to prevent excessive hemorrhage from damaged blood vessels. Under normal conditions, clotting factors in the bloodstream spontaneously interact with damaged vessels to create a blood clot that plugs the leaking vessel. Obviously, inadequate blood clotting is harmful in that even minor vessel damage can lead to excessive blood loss. Overactive clotting is also detrimental because it will lead to thrombogenesis (i.e., the abnormal formation of blood clots, or thrombi).1Thrombus formation may lead directly to vessel occlusion and tissue infarction. Also, a piece of a thrombus may dislodge, creating an embolism that causes infarction elsewhere in the body, such as in the lungs or brain.