tacrolimus (oral, IV) (ta-kroe-li-mus)
tacrolimus (topical) (ta-kroe-li-mus)
Oral, IV: Prevention of organ rejection in patients who have undergone allogenic liver, kidney, or heart transplantation (used concurrently with corticosteroids).
Topical: Moderate-to-severe atopic dermatitis in nonimmunocompromised patients who do not respond to or cannot tolerate alternative, conventional therapies.
Inhibits T-lymphocyte activation. Therapeutic Effects: Prevention of transplanted organ rejection (oral, IV). Improvement in signs/symptoms of atopic dermatitis (topical).
CNS: SEIZURES, dizziness, headache, insomnia, tremor, abnormal dreams, agitation, anxiety, confusion, emotional lability, depression, hallucinations, psychoses, somnolence. EENT: abnormal vision, amblyopia, tinnitus. Resp: cough, pleural effusion, asthma, bronchitis, pharyngitis, pneumonia, pulmonary edema. CV: hypertension, peripheral edema, QTc prolongation. GI: GI BLEEDING, abdominal pain, anorexia, ascites, constipation, diarrhea, dyspepsia, ↑ liver function studies, nausea, vomiting, cholangitis, cholestatic jaundice, dysphagia, flatulence, ↑ appetite, oral thrush. GU: nephrotoxicity, urinary tract infection. Derm: pruritus, rash, alopecia, herpes simplex, hirsutism, sweating, photosensitivity. Endo: hyperglycemia. F and E: hyperkalemia, hyperlipidemia, hypokalemia, hypomagnesemia, hypophosphatemia, hyperphosphatemia, hyperuricemia, hypocalcemia, hyponatremia, metabolic acidosis, metabolic alkalosis. Hemat: anemia, leukocytosis, leukopenia, thrombocytopenia, coagulation defects. MS: arthralgia, hypertonia, leg cramps, muscle spasm, myalgia, myasthenia, osteoporosis. Neuro: paresthesia, neuropathy. Misc: ALLERGIC REACTIONS, INCLUDING ANAPHYLAXIS, fever, generalized pain, abnormal healing, chills, ↑ risk of lymphoma/skin cancer.