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reteplase (re-te-plase)



Therapeutic: thrombolytics

Pharmacologic: plasminogen activators


Acute myocardial infarction (MI). Unlabeled Use: Occluded central venous access devices. Deep venous thrombosis (DVT). Acute peripheral arterial thrombosis.


Directly converts plasminogen to plasmin, which then degrades clot-bound fibrin. Therapeutic Effects: Lysis of thrombi in coronary arteries, with improvement of ventricular function, and reduced risk of heart failure or death. Restoration of cannula or catheter function. Restoration of blood flow following lysis of peripheral venous or arterial thrombi.

Adverse Reactions/Side Effects

CNS: INTRACRANIAL HEMORRHAGE. EENT: epistaxis, gingival bleeding. Resp: bronchospasm, hemoptysis. CV: reperfusion arrhythmias, hypotension, RECURRENT ISCHEMIA/THROMBOEMBOLISM. GI: GI BLEEDING, nausea, RETROPERITONEAL BLEEDING, vomiting. GU: GU TRACT BLEEDING. Derm: ecchymoses, flushing, urticaria.

Hemat: BLEEDING. Local: hemorrhage at injection site, phlebitis at injection site. MS: musculoskeletal pain.



Examination and Evaluation

  • Watch for signs of bleeding and hemorrhage, including bleeding gums, nosebleeds, unusual bruising, coughing up blood, black/tarry stools, hematuria, or a fall in hematocrit or blood pressure. Be especially alert for signs of intracranial bleeds, including sudden severe headache, confusion, nausea, vomiting, paralysis, numbness, speech problems, and visual disturbances. Notify physician or nursing staff immediately if these signs occur.

  • Be alert for signs of recurrent cardiac ischemia (chest pain, pain radiating into the arm or jaw, shortness of breath, dizziness, sweating, anxiety) or recurrent peripheral arterial thrombosis (pain, cramping, coldness, cyanosis in the affected limb). Notify physician or nursing staff immediately if these signs occur.

  • Monitor signs of recurrent thromboembolism and pulmonary embolism, including shortness of breath, chest pain, cough, and bloody sputum. Notify physician immediately, and request objective tests (Doppler ultrasound, lung scan, others) if PE is suspected.

  • Monitor signs of allergic reactions or anaphylaxis, including pulmonary symptoms (tightness in the throat and chest, wheezing, cough, dyspnea) or skin reactions (rash, pruritus, urticaria). Notify physician or nursing staff immediately if these reactions occur.

  • Assess heart rate, ECG, and heart sounds when cardiac perfusion is restored (see Appendixes G, H). Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness.

  • Assess blood pressure, especially for the first few days after infusion. Report low blood pressure (hypotension), especially if patient experiences dizziness or syncope.

  • Assess any muscle of joint pain to rule out musculoskeletal pathology or hemorrhage; that is, try to determine if pain is drug-induced rather than caused by anatomical or biomechanical problems. Be especially concerned about back pain that could indicate retroperitoneal bleeding.

  • Assess injection site during and after IV administration, and report signs of bleeding or phlebitis (local pain, swelling, inflammation).


  • Use caution with ...

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