olopatadine (nasal spray) (oh-loe-pat-ah-deen)
Therapeutic: allergy, cold, and cough remedies
Relief of symptoms of allergic rhinitis.
Antagonizes the effects of histamine at histamine1 receptor sites; does not bind to or inactivate histamine. Therapeutic Effects: Decreased symptoms of histamine excess, including rhinorrhea, sneezing, and nasal itching.
Adverse Reactions/Side Effects
CNS: drowsiness, headache. EENT: epistaxis, nasal perforation, nasal ulcerations, pharyngolaryngeal pain, postnasal drip. GI: bitter taste. Resp: cough.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Report signs of nasal or pharyngeal problems such as nosebleeds, nasal pain, ulceration, or increased postnasal drip.
Advise patient not to exceed the recommended dose or frequency of intranasal applications.
Advise patient to avoid alcohol and other CNS depressants because of the increased risk of sedation and adverse effects.
Instruct patient and family/caregivers to report other troublesome side effects such as severe or prolonged headache, drowsiness, cough, or bitter taste.
Absorption: 57% absorbed from nasal mucosa.
Metabolism and Excretion: Minimal metabolism; 70% eliminated in urine mostly as unchanged drug; 17% fecal elimination.
Contraindicated in: None noted.
Use Cautiously in: Nasal pathology other than allergic rhinitis; Geri: Dose cautiously in elderly patients; consider age-related decrease in organ function and concurrent medications; Lactation/OB: Use in pregnancy or lactation only when maternal benefit outweighs fetal risk; Pedi: Safe use in children <12 yr not established.
Drug-Drug: ↑ CNS depression may occur with alcohol; avoid concurrent use.
Intranasal (Adults and Children ≥12 yr): 2 sprays in each nostril bid.
Nasal spray: 665 mcg/100 μL (0.6%) spray in 30.5-g bottle (provides 240 metered sprays).