estradiol acetate (es-tra-dye-ole as-e-tate)
estradiol cypionate (es-tra-dye-ole sip-ee-oh-nate)
depGynogen, Depo-Estradiol, Depogen, Dura-Estrin, E-Cypionate, Estragyn LA 5, Estro-Cyp, Estrofem, Estroject-LA, Estro-L.A
estradiol valerate (es-tra-dye-ole val-er-ate)
Clinagen LA, Delestrogen, Dioval, Duragen, Estra-L, Estro-Span, Femogex, Gynogen L.A, Menaval, Valergen
estradiol topical emulsion
estradiol topical gel
Divigel, Elestrin, EstroGel
estradiol transdermal spray
estradiol transdermal system
Alora, Climara, Esclim, Estraderm, FemPatch, Menostar, Vivelle
estradiol vaginal tablet
estradiol vaginal ring
PO, IM, Topical, Transdermal: Replacement of estrogen (hormone replacement therapy, HRT) to diminish moderate-to-severe vasomotor symptoms of menopause and of various estrogen-deficiency states, including Female hypogonadism, Ovariectomy, Primary ovarian failure. Treatment and prevention of postmenopausal osteoporosis (not vaginal dose forms). PO: Inoperable metastatic postmenopausal breast or prostate carcinoma. Vaginal: Management of atrophic vaginitis that may occur with menopause (low dose), bothersome systemic symptoms of menopause (higher dose). Concurrent use of progestin is recommended during cyclical therapy to decrease the risk of endometrial carcinoma in patients with an intact uterus.
Estrogens promote growth and development of female sex organs and the maintenance of secondary sex characteristics in women. Metabolic effects include reduced blood cholesterol, protein synthesis, and sodium and water retention. Therapeutic Effects: Restoration of hormonal balance in various deficiency states, including menopause. Treatment of hormone-sensitive tumors.
Adverse Reactions/Side Effects
CNS: headache, dizziness, lethargy. EENT: intolerance to contact lenses, worsening of myopia or astigmatism. CV: MI, THROMBOEMBOLISM, edema, hypertension. GI: nausea, weight changes, anorexia, increased appetite, jaundice, vomiting. GU: women—amenorrhea, dysmenorrhea, breakthrough bleeding, cervical erosions, loss of libido, vaginal candidiasis; men—erectile dysfunction, testicular atrophy. Derm: oily skin, acne, pigmentation, urticaria. Endo: gynecomastia (men), hyperglycemia. F and E: hypercalcemia, sodium and water retention. MS: leg cramps. Misc: breast tenderness.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Be alert for signs of myocardial infarction, especially during exercise. Seek immediate medical assistance if symptoms of MI develop, including sudden chest pain, pain radiating into the arm or jaw, shortness of breath, dizziness, sweating, anxiety, and nausea.
Monitor signs of venous thrombosis (lower extremity swelling, warmth, erythema, tenderness) and thromboembolism (shortness of breath, chest pain, cough, bloody sputum). Notify physician immediately, and request objective tests (Doppler ultrasound, lung scan, others) if thromboembolism is suspected.
Assess blood pressure (BP) and compare to normal values (See Appendix F). Report a sustained increase in BP (hypertension) to the physician.
Assess peripheral edema using girth measurements, volume displacement, and measurement of pitting edema (see Appendix N). Report increased swelling in feet and ankles or a sudden increase in body weight due to fluid retention.
Monitor signs of ...