Therapeutic: ocular agents
Treatment of itching associated with allergic conjunctivitis.
Acts as a histamine H1 receptor antagonist; also inhibits the release of histamine from mast cells; does not bind to or inactivate histamine. Therapeutic Effects: Decreased ocular itching associated with allergic conjunctivitis.
Adverse Reactions/Side Effects
CNS: headache. EENT: nasopharyngitis. GI: taste in mouth following instillation.
PHYSICAL THERAPY IMPLICATIONS
Examination and Evaluation
Check that the patient and family or caregivers understand ophthalmic application procedures and adhere to the recommended dosing schedule.
Instruct patient and family/caregivers to report other troublesome side effects such as severe or prolonged headache, altered taste, or inflammation of the nose and pharynx.
Absorption: Some systemic absorption follows ophthalmic administration.
Metabolism and Excretion: Minimally metabolized by the liver; 75–90% excreted unchanged in urine
TIME/ACTION PROFILE (antihistaminic activity)
|ROUTE ||ONSET ||PEAK ||DURATION |
|ophthalmic ||within 15 min ||1–2 hr* ||12 hr |
Contraindicated in: Hypersensitivity.
Use Cautiously in: Contact lens use OB: Use during pregnancy if potential maternal benefit justifies the potential risk to fetus; Lactation: Use cautiously during breastfeeding; Pedi: Safe and effective use in children <2 yr has not been established.
Ophthalmic (Adults): 1 drop in affected eye(s) twice daily.
Ophthalmic solution: 1.5%